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EpiX Technology

Airway Tissues
Skin Tissues

CR Technology

Airway Tissues
Head, Neck, Glandular & GI Tract Tissues
Mammary & Prostate Tissues
Oncology Applications

Long-Term Culture And Cloning Of Primary Human Bronchial Basal Cells That Maintain Multipotent Differentiation Capacity And CFTR Channel Function. Peters-Hall JR, Coquelin ML, Torres MJ, LaRanger R, Alabi BR, Sho S, Calva-Moreno JF, Thomas PJ, Shay JW. (2018) Am J Physiol Lung Cell Mol Physiol. May 3.  PMID: 29722564

Reconstituting Mouse Lungs With Conditionally Reprogrammed Human Bronchial Epithelial Cells. LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen CT, Wright WE, Shay JW. (2018) Tissue Eng Part A. Apr;24(7-8):559-568. PMID: 28726588

Generation Of Human Nasal Epithelial Cell Spheroids For Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study. Brewington JJ, Filbrandt ET, LaRosa FJ 3rd, Moncivaiz JD, Ostmann AJ, Strecker LM, Clancy JP. (2018) J Vis Exp. Apr 11;(134). PMID: 29708545

Patient-Derived Conditionally Reprogrammed Cells Maintain Intra-Tumor Genetic Heterogeneity. Correa BRS, Hu J, Penalva LOF, Schlegel R, Rimm DL, Galante PAF, Agarwal S. (2018) Sci Rep. Mar 6;8(1):4097. PMID: 29511269

Conditional Reprogramming Of Pediatric Airway Epithelial Cells: A New Human Model To Investigate Early-Life Respiratory Disorders. Wolf S, Perez GF, Mukharesh L, Isaza N, Preciado D, Freishtat RJ, Pillai D, Rose MC, Nino G. (2017) Pediatr Allergy Immunol. Dec;28(8):810-817. PMID: 28981980

Conditionally Reprogrammed Primary Airway Epithelial Cells Maintain Morphology, Lineage And Disease Specific Functional Characteristics.  Martinovich KM, Iosifidis T, Buckley AG, Looi K, Ling KM, Sutanto EN, Kicic-Starcevich E, Garratt LW, Shaw NC, Montgomery S, Lannigan FJ, Knight DA, Kicic A, Stick SM. (2017) Sci Rep. Dec 21;7(1):17971. PMID: 29269735

Mutation-Specific Downregulation Of CFTR2 Variants By Gating Potentiators. Avramescu RG, Kai Y, Xu H, Bidaud-Meynard A, Schnúr A, Frenkiel S, Matouk E, Veit G, Lukacs GL. (2017) Hum Mol Genet. Dec 15;26(24):4873-4885. PMID: 29040544

Pharmacological Rescue Of Conditionally Reprogrammed Cystic Fibrosis Bronchial Epithelial Cells.  Gentzsch M, Boyles SE, Cheluvaraju C, Chaudhry IG, Quinney NL, Cho C, Dang H, Liu X, Schlegel R, Randell SH. (2017) Am J Respir Cell Mol Biol. May;56(5):568-574. PMID: 27983869

Correctors And Potentiators Rescue Function Of The Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product. Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS. (2017) J Biol Chem. Jan 20;292(3):771-785. PMID: 27895116

Airway Progenitor Clone Formation Is Enhanced By Y-27632-Dependent Changes In The Transcriptome. Reynolds SD, Rios C, Wesolowska-Andersen A, Zhuang Y, Pinter M, Happoldt C, Hill CL, Lallier SW,Cosgrove GP, Solomon GM, Nichols DP, Seibold MA  (2016) Am J Respir Cell Mol Biol. [ePub]. PMID: 27144410

Rapid Expansion Of Human Epithelial Stem Cells Suitable For Airway Tissue Engineering. Butler CR, Hynds RE, Gowers KHC, Lee DDH, Brown JM, Crowley C,Teixeira VH, Smith CM, Urbani L, Hamilton NJ, Thakrar RM, Booth HL, Birchall MA, De Coppi P, Giangreco A, O’Callaghan C, Janes SM  (2016) Am J Respir Crit Care Med. [Epub]. PMID: 26840431

Patient-Derived Models Of Acquired Resistance Can Identify Effective Drug Combinations For Cancer. Crystal AS, Shaw AT, Sequist LV, Friboulet L, Niederst MJ, Lockerman EL, Frias RL, Gainor JF, Amzallag A, Greninger P, Lee D, Kalsy A, Gomez-Caraballo M, Elamine L, Howe E, Hur W, Lifshits E, Robinson HE, Katayama R, Faber AC, Awad MM, Ramaswamy S, Mino-Kenudson M, Iafrate AJ, Benes CH, Engelman JA (2014) Science 346(6216):1480-1486. PMID: 25394791

Use Of Reprogrammed Cells To Identify Therapy For Respiratory Papillomatosis. Yuan H, Myers S, Wang J, Zhou D, Woo JA, Kallakury B, Ju A, Bazylewicz M, Carter YM, Albanese C, Grant N, Shad A, Dritschilo A, Liu X, Schlegel R (2012) New Engl J Med 367(13):1220-1227. PMID: 23013073