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EpiX Technology

Airway Tissues
Skin Tissues

CR Technology

Airway Tissues
Head, Neck, Glandular & GI Tract Tissues
Mammary & Prostate Tissues
Oncology Applications

Patient-Derived Conditionally Reprogrammed Cells Maintain Intra-Tumor Genetic Heterogeneity. Correa BRS, Hu J, Penalva LOF, Schlegel R, Rimm DL, Galante PAF, Agarwal S. (2018) Sci Rep. Mar 6;8(1):4097. PMID: 29511269

Generation Of Stable PDX Derived Cell Lines Using Conditional Reprogramming. Borodovsky A, McQuiston TJ, Stetson D, Ahmed A, Whitston D, Zhang J, Grondine M, Lawson D, Challberg SS, Zinda M, Pollok BA, Dougherty BA, D'Cruz CM. (2017) Mol Cancer. Dec 6;16(1):177. PMID: 29212548

Conditional Reprogramming And Long-Term Expansion Of Normal And Tumor Cells From Human Biospecimens. Liu X, Krawczyk E, Suprynowicz FA, Palechor-Ceron N, Yuan H, Dakic A, Simic V, Zheng YL, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang DG, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell SH, Albanese C, Agarwal S, Schlegel R. (2017) Nat Protoc. Feb;12(2):439-451. PMID: 28125105

Conditionally Reprogrammed Cells Represent A Stem-Like State Of Adult Epithelial Cells. Suprynowicz FA, Upadhyay G, Krawczyk E, Kramer SC, Hebert JD, Liu X, Yuan H, Cheluvaraju C, Clapp PW, Boucher RC Jr, Kamonjoh CM, Randell SH, Schlegel R (2012) P Natl Acad Sci USA 109(49):20035-20040. PMID: 23169653

Airway Progenitor Clone Formation Is Enhanced By Y-27632-Dependent Changes In The Transcriptome. Reynolds SD, Rios C, Wesolowska-Andersen A, Zhuang Y, Pinter M, Happoldt C, Hill CL, Lallier SW,Cosgrove GP, Solomon GM, Nichols DP, Seibold MA  (2016) Am J Respir Cell Mol Biol. [ePub]. PMID: 27144410

Radiation Induces Diffusible Feeder Cell Factor(S) That Cooperate With ROCK Inhibitor To Conditionally Reprogram And Immortalize Epithelial Cells. Palechor-Ceron N, Suprynowicz FA, Upadhyay G, Dakic A, Minas T, Simic V, Johnson M, Albanese C, Schlegel R, Liu X (2013) Am J Pathol 183(6): 1862-1870. PMID: 24096078

ROCK Inhibitor And Feeder Cells Induce The Conditional Reprogramming Of Epithelial Cells. Ory V, Chapman S, Yuan H, Albanese C, Kallakury B, Timofeeva OA, Nealon C, Dakic A, Simic V, Haddad BR, Rhim JS, Dritschilo A, Riegel A, McBride A, Schlegel R(2012) Am J Pathol 180(2):599-607. PMID: 22189618

Making Every Cell Like HeLa A Giant Step For Cell Culture. Aggaral S, Rimm DL(2011) Am J Patho 180(2):443-445. PMID: 22192626